Sometimes intermediates. Do the job!
Identifieur interne : 003C98 ( Main/Exploration ); précédent : 003C97; suivant : 003C99Sometimes intermediates. Do the job!
Auteurs : Rolf Hilgenfeld [Allemagne] ; Ksenia PumporSource :
- Chemistry & biology [ 1074-5521 ] ; 2006.
Descripteurs français
- KwdFr :
- Antiviraux (), Antiviraux (pharmacologie), Benzothiazoles (), Benzothiazoles (pharmacologie), Cysteine endopeptidases (), Esters (), Esters (pharmacologie), Inhibiteurs de protéases (), Inhibiteurs de protéases (pharmacologie), Lopinavir, Pyrimidinones (pharmacologie), Pyrimidinones (synthèse chimique), Spécificité du substrat, Tests de sensibilité microbienne, Virus du SRAS (), Virus du SRAS (pathogénicité).
- MESH :
- pathogénicité : Virus du SRAS.
- pharmacologie : Antiviraux, Benzothiazoles, Esters, Inhibiteurs de protéases, Pyrimidinones.
- synthèse chimique : Pyrimidinones.
- Antiviraux, Benzothiazoles, Cysteine endopeptidases, Esters, Inhibiteurs de protéases, Lopinavir, Spécificité du substrat, Tests de sensibilité microbienne, Virus du SRAS.
English descriptors
- KwdEn :
- Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Benzothiazoles (chemistry), Benzothiazoles (pharmacology), Cysteine Endopeptidases (chemistry), Esters (chemistry), Esters (pharmacology), Lopinavir, Microbial Sensitivity Tests, Protease Inhibitors (chemistry), Protease Inhibitors (pharmacology), Pyrimidinones (chemical synthesis), Pyrimidinones (pharmacology), SARS Virus (drug effects), SARS Virus (pathogenicity), Substrate Specificity.
- MESH :
- chemical , chemical synthesis : Pyrimidinones.
- chemical , chemistry : Antiviral Agents, Benzothiazoles, Cysteine Endopeptidases, Esters, Protease Inhibitors.
- chemical , pharmacology : Antiviral Agents, Benzothiazoles, Esters, Protease Inhibitors, Pyrimidinones.
- chemical : Lopinavir.
- drug effects : SARS Virus.
- pathogenicity : SARS Virus.
- Microbial Sensitivity Tests, Substrate Specificity.
Abstract
The SARS coronavirus main proteinase is a prime target for antiviral therapy. In this issue of Chemistry & Biology, Wu et al. describe potent inhibition of the enzyme by benzotriazole esters, which were originally obtained as intermediates in the synthesis of lopinavir derivatives .
DOI: 10.1016/j.chembiol.2006.03.002
PubMed: 16638527
Affiliations:
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Le document en format XML
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Do the job!</title><author><name sortKey="Hilgenfeld, Rolf" sort="Hilgenfeld, Rolf" uniqKey="Hilgenfeld R" first="Rolf" last="Hilgenfeld">Rolf Hilgenfeld</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck</wicri:regionArea><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Pumpor, Ksenia" sort="Pumpor, Ksenia" uniqKey="Pumpor K" first="Ksenia" last="Pumpor">Ksenia Pumpor</name></author></analytic><series><title level="j">Chemistry & biology</title><idno type="ISSN">1074-5521</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Benzothiazoles (chemistry)</term><term>Benzothiazoles (pharmacology)</term><term>Cysteine Endopeptidases (chemistry)</term><term>Esters (chemistry)</term><term>Esters (pharmacology)</term><term>Lopinavir</term><term>Microbial Sensitivity Tests</term><term>Protease Inhibitors (chemistry)</term><term>Protease Inhibitors (pharmacology)</term><term>Pyrimidinones (chemical synthesis)</term><term>Pyrimidinones (pharmacology)</term><term>SARS Virus (drug effects)</term><term>SARS Virus (pathogenicity)</term><term>Substrate Specificity</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux ()</term><term>Antiviraux (pharmacologie)</term><term>Benzothiazoles ()</term><term>Benzothiazoles (pharmacologie)</term><term>Cysteine endopeptidases ()</term><term>Esters ()</term><term>Esters (pharmacologie)</term><term>Inhibiteurs de protéases ()</term><term>Inhibiteurs de protéases (pharmacologie)</term><term>Lopinavir</term><term>Pyrimidinones (pharmacologie)</term><term>Pyrimidinones (synthèse chimique)</term><term>Spécificité du substrat</term><term>Tests de sensibilité microbienne</term><term>Virus du SRAS ()</term><term>Virus du SRAS (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Pyrimidinones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Benzothiazoles</term><term>Cysteine Endopeptidases</term><term>Esters</term><term>Protease Inhibitors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Benzothiazoles</term><term>Esters</term><term>Protease Inhibitors</term><term>Pyrimidinones</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Lopinavir</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Benzothiazoles</term><term>Esters</term><term>Inhibiteurs de protéases</term><term>Pyrimidinones</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Pyrimidinones</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Microbial Sensitivity Tests</term><term>Substrate Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Antiviraux</term><term>Benzothiazoles</term><term>Cysteine endopeptidases</term><term>Esters</term><term>Inhibiteurs de protéases</term><term>Lopinavir</term><term>Spécificité du substrat</term><term>Tests de sensibilité microbienne</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The SARS coronavirus main proteinase is a prime target for antiviral therapy. In this issue of Chemistry & Biology, Wu et al. describe potent inhibition of the enzyme by benzotriazole esters, which were originally obtained as intermediates in the synthesis of lopinavir derivatives .</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Pumpor, Ksenia" sort="Pumpor, Ksenia" uniqKey="Pumpor K" first="Ksenia" last="Pumpor">Ksenia Pumpor</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Hilgenfeld, Rolf" sort="Hilgenfeld, Rolf" uniqKey="Hilgenfeld R" first="Rolf" last="Hilgenfeld">Rolf Hilgenfeld</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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